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Cobalt(II) chloride as a novel and efficient catalyst for the synthesis of 1,2,5-trisubstituted pyrroles under solvent-free conditions

✍ Scribed by Surya K. De

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
104 KB
Volume
19
Category
Article
ISSN
1042-7163

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✦ Synopsis

Abstract

CoCl~2~ is used as an efficient catalyst in the Paal–Knorr condensation of 2,5‐hexadione with primary amines under solvent‐free conditions, leading to the formation of pyrrole derivatives in excellent yield. This method is very easy, rapid, and high yielding reaction for the synthesis N‐substituted pyrrole derivatives. Β© 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:592–595, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20482

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