𝔖 Bobbio Scriptorium
✦   LIBER   ✦

CO/Alkene Copolymers as a Promising Class of Biocompatible Materials, 1. Examination of the In Vitro Toxicity

✍ Scribed by P. Reuter; R. Fuhrmann; A. Mücke; J. Voegele; B. Rieger; R.-P. Franke

Book ID
102933717
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
570 KB
Volume
3
Category
Article
ISSN
1616-5187

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Novel 1,4‐polyketones were synthesized by a Pd^II^ catalyzed copolymerization reaction from cheap technical monomers. The spectrum of mechanical properties ranges from highly crystalline, hard materials to thermoplastic, soft elastomers. The hydrophilicity of the surface is adjustable from nonpolar to highly polar by a proper choice of the α‐olefin component. This control of polymer properties is a basis for the development of new biocompatible materials. The results of standardized as well as more specific in vitro tests clearly demonstrate the nontoxicity of the investigated copolymers.

Polyketone synthesis.

magnified imagePolyketone synthesis.

📜 SIMILAR VOLUMES

CO/Alkene Copolymers as a Promising Clas
CO/Alkene Copolymers as a Promising Class of Biocompatible Materials, 2. Bone Growth Directed Performance of Bone Marrow Cell Spreading
✍ W. Röhlke; R. Fuhrmann; R.-P. Franke; A. Mücke; J. Voegele; B. Rieger 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 265 KB

## Abstract The influence of polymer polarity of three different CO/alkene copolymers on the production of bone materials by human bone marrow cells was demonstrated. The effects were measured by a specific immunohistochemical glycoprotein (osteonectin, osteopontin) test. Von Kossa staining, as an

Acute and Chronic Toxicity of Veratrum V
Acute and Chronic Toxicity of Veratrum Viride††The Veratrum viride studied was the whole-powdered drug marketed by Irwin, Neisler & Co. under the name, Vertavis. The work reported herein was supported by a grant from this firm. The batch of powder used in these experiments was stated by the manufacturer to have been assayed biologically by the Craw method on Daphnia magna. One Craw unit of the material studied was stated to be 15.6mg. With regard to this assay, Mr. R. O. Craw has been so kind as to allow us to publish a brief explanation: A reference lot of Yerolrum oirid; powder was set-aside as a standard and a 10% w/v aqueous extract was made of this powder. The average median length of life in 50 assays of 1000 daphnia on immersion in the solution was determined to be 2.22 hours. The daphnia were considered dead when the heart was found to be in systolic standstill on microscopic examination. Succeeding lots of powder were assayed and their potency determined by relating the median length of life of daphnia to 2.22 hours, which is one unit. Twenty assays of 10 animals each were used on each lot of powder.‡‡The authors wish to thank Dr. J. F. A.,McManus of the Department of Pathology for a pathologic report on the tissues, and Mr. James Thomas and Mrs. Bobby E. Teague for technical assistance.
✍ Perdue, Adoline S. ;Bell, Frances ;Starnes, W.R. ;Hitchcock, Philip ;Teague, R.S 📂 Article 📅 1950 🏛 Elsevier ⚖ 346 KB 👁 2 views