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Coagulation factor XIII: Genetic linkage studies with F13B

✍ Scribed by Dr. Klaus Bender; Siegbert Bissbort; Anne Klein; Gottfried Mauff; Antonia Mayerová; Marcela Nagel; Annette Schilling; Thomas F. Wienker; D. C. Rao


Book ID
102224597
Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
304 KB
Volume
4
Category
Article
ISSN
0741-0395

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✦ Synopsis


Linkage relations of the F13B gene with 38 marker genes are analyzed, which, along with the data of earlier reports on the same subject, brings the number of comparisons to a total of 49. Practically all the lod scores are totally negative. This will mean that the F13B gene can hardly be located on the chromosomes/ chromosome arms lp, 2p, 4q, 6p, 14p, 15p, 20q, 21p, 22 and also not on longer segments of 3q, 6q, 7q, 9p, 9q, llq, 13q, 14q, 16p, and 16q.


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The plasmas of two groups of subjects were examined for blood coagulation Factor XIII-A (FXIII-A, F13A) by electrophoresis in agarose using a Tris-EDTA-borate buffer to separate the common variants, F13A\*1, F13A\*2, and F13A\*3. Dimeric subunits were visualized in UV light as monodansyl cadaverine