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Coadministration of P-Glycoprotein Modulators on Loperamide Pharmacokinetics and Brain Distribution

โœ Scribed by Montesinos, R. N.; Moulari, B.; Gromand, J.; Beduneau, A.; Lamprecht, A.; Pellequer, Y.

Book ID
121861018
Publisher
American Society for Pharmacology and Experimental Therapeutics
Year
2014
Tongue
English
Weight
240 KB
Volume
42
Category
Article
ISSN
0090-9556

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Effects of coadministration of dietary supplement biochanin A (BA) on the pharmacokinetics of three P-glycoprotein substrates, paclitaxel, digoxin, and fexofenadine, were investigated in rats. With BA coadministration, the oral bioavailability and peak plasma concentration were markedly increased by