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Coadministration of Branched-Chain Amino Acids and Lipopolysaccharide Causes Matrix Metalloproteinase Activation and Blood–Brain Barrier Breakdown

✍ Scribed by Scaini, Giselli; Morais, Meline O. S.; Galant, Leticia S.; Vuolo, Francieli; Dall’Igna, Dhébora M.; Pasquali, Matheus A. B.; Ramos, Vitor M.; Gelain, Daniel P.; Moreira, Jose Claudio F.; Schuck, Patrícia F.; Ferreira, Gustavo C.; Soriano, Francisco G.; Dal-Pizzol, Felipe; Streck, Emilio L.

Book ID
121580712
Publisher
Springer
Year
2014
Tongue
English
Weight
592 KB
Volume
50
Category
Article
ISSN
0893-7648

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## Abstract Blood‐brain barrier (BBB) formed by brain microvascular endothelial cells (BMVEC) regulates the passage of molecules and leukocytes in and out of the brain. Activation of matrix metalloproteinases (MMPs) and alteration of basement membrane (BM) associated with BBB injury was documented