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Coactivation of direct and indirect pathways: Insights into the basal ganglia and normal movement control

✍ Scribed by Edwards, Mark J.; Saifee, T.A.

Book ID
121743718
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
46 KB
Volume
28
Category
Article
ISSN
0885-3185

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Dopamine (DA) neurons exist in two activity states; either spontaneously firing or quiescent and nonfiring. When faced with a behavioral demand, the quiescent DA neurons can be activated to facilitate normal motor output. Levodopa appears to increase DA output by activating these nonfiring neurons;