Coacervate formation by inorganic salts with benzalkonium chloride

✍ Scribed by Devendra Shah; Bernard Ecanow; Reuben Balagot

• Publisher: John Wiley and Sons
• Year: 1973
• Tongue: English
• Weight: 255 KB
• Volume: 62
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600621046

✦ Synopsis

Coacervate Formation by Inorganic Salts with Benzalkonium Chloride Trimethylsilyl Derivatives of Cannabinoids rnle ( -)-~'-rroiis-Te'ecrahydrocannabinolic acid 502 ( -)-~'-truirs-Te'errahydrocannabivarinic acid 474 Caniiabidiolic acid Cannabidivarinic acid 574 546

acid derivatives in fresh C. satiurr L. (S), so do the CsH7 (divarinyl group) side chains. GLC-mass spectrometry analysis of an lndian (IN-B) variant, silylated according to a reported procedure (9), contained a significant m/e at 546, corresponding to the trisilylated (trimethylsilyl ester bisether) derivative of I. Additionally, a significant m/e at 474 is indicative of disilylated (trimethylsilyl ester-ether) 11. These data agree with the mass spectral data obtained for silylated acid derivatives of VIll and V, having rnje's of 574 and 502, respectively (Table ). TLC was employed for identification of 111, which has a relative retention time corresponding to IV and Vl11. Compound 111 was not clearly observed in fresh samples of cannabis but was observed when samples containing 11 were heated. Thus, no data are presently available on the acid derivative of 111. Propyl homologs are, indeed, found in aerial parts of C. saliva L. plant material from many geographical locations. The abundances of propyl homologs vary, as do the pentyl homologs, in regard to geographical origin. However, we do not believe it feasible t o determine exact geographic origin using the propyl homologs as "Locators." Moreover, the propyl homologs exist predominately as their carboxylic acid derivatives as do the pentyl homologs.