CO2 laser urethroplasty in the rabbit: A preclinical model

✍ Scribed by Theodore J. Choma; Dix P. Poppas; Harry J. Presberg; Maria Cundiff; Steven M. Schlossberg

• Book ID: 102467489
• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 493 KB
• Volume: 12
• Category: Article
• ISSN: 0196-8092
• DOI: 10.1002/lsm.1900120612

✦ Synopsis

Abstract

Our previous work has shown that the CO~2~ laser can be successfully used in urethral reconstruction in a rat model. This new experiment investigates the use of the CO~2~ laser to perform a patch graft urethroplasty in the rabbit, as a preclinical model to its use in the repair of hypospadias in humans. Using sterile technique, a patch graft of preputial skin was welded in the repair of a standardized urethral defect in 10 rabbits. In another cohort, the same urethral defect was repaired using standard microsuture technique. In a control group the patch graft was placed with microsuture in a nonwatertight fashion. All animals were followed for 3 weeks. Histologic and radiologic analyses were done in a blinded fashion. Our study showed that CO~2~ laser repair, when compared to microsuture in urethral reconstruction, required 40% less operative time and produced better graft healing and less intraluminal scarring. © 1992 Wiley‐Liss, Inc.