Over-expression of APAF-1 and caspase-9
Over-expression of APAF-1 and caspase-9 augments radiation-induced apoptosis in U-373MG glioma cells
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Nobusada Shinoura; Shinya Sakurai; Akio Asai; Takaaki Kirino; Hirofumi Hamada
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Article
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2001
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John Wiley and Sons
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French
β 436 KB
The p53 tumor-suppressor gene plays a critical role in radiation-induced apoptosis. Several genes, including Bax and Fas, are involved in p53-mediated apoptosis, and their over-expression enhances the degree of radiation-induced apoptosis. Apaf-1 and caspase-9 have been reported to be downstream com