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Co-survival of the fittest few: mosaic amplification of receptor tyrosine kinases in glioblastoma

โœ Scribed by Feng Chen; Li Ding


Book ID
118727774
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
122 KB
Volume
13
Category
Article
ISSN
1465-6906

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Fusion of FIG to the receptor tyrosine k
โœ Alain Charest; Keara Lane; Kevin McMahon; Julie Park; Elizabeth Preisinger; Hele ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 757 KB

The transmembrane proto-oncogene receptor tyrosine kinase (RTK) ROS is an orphan receptor that is aberrantly expressed in neoplasms of the central nervous system. Here, we report the fusion of its carboxy-terminal kinase domain to the amino-terminal portion of a protein called FIG (Fused in Glioblas