𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Co-receptors of B lymphocytes

✍ Scribed by Lorraine O'Rourke; Reuben Tooze; Douglas T Fearon

Book ID
104358702
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
574 KB
Volume
9
Category
Article
ISSN
0952-7915

No coin nor oath required. For personal study only.

✦ Synopsis

The past year has seen advances in our understanding of accessory membrane proteins that modulate the B cell response to antigen-receptor stimulation. The generation of complement receptor deficient mice has reinforced our appreciation of the importance of complement receptors in the B cell response to antigen. The association of inositol polyphosphate 5-phosphatase with FcgammaRIIB suggests another mechanism, in addition to recruitment of the phosphotyrosine phosphatase SHP-1, by which secreted immunoglobulin can limit further response to antigen. The in vivo function of CD22 in regulating the threshold of antigen-receptor signalling has been shown using CD22-deficient mice. Lastly, B cell receptor signalling in the B-1 subset of B lymphocytes has been demonstrated to be negatively regulated by CD5.

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