Co-permeant enhancement of drug transmission rates through silicone rubber
✍ Scribed by Most, Clark F.
- Publisher
- John Wiley and Sons
- Year
- 1972
- Tongue
- English
- Weight
- 568 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0021-9304
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✦ Synopsis
In vitro transmission rates of benzocaine were measured to determine the feasibility of augmenting the permeability of silicone rubber implants by introduction of co-permeant plasticizers into the systems. It was shown that permeation can be enhanced or inhibited depending on the co-permeant used, including increased mass transfer of methylene blue, previously reported to be a non-permeant. Factors influencing such potentiation or diminution are thought to be solubility relationships among all components present, diffusivity, molecular volumes and mobilities of the co-permeants, hydrogen bonding capabilities, and potential for internal segmental motion of polymeric plasticizers.