✦ LIBER ✦

Co-overexpression of p21 and Ki-67 in head and neck squamous cell carcinoma relative to a significantly poor prognosis

✍ Scribed by Claude A. Fischer; Minoa Jung; Inti Zlobec; Edith Green; Claudio Storck; Luigi Tornillo; Alessandro Lugli; Markus Wolfensberger; Luigi M. Terracciano

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 334 KB
Volume: 33
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.21440

No coin nor oath required. For personal study only.

✦ Synopsis

Background. Head and neck squamous cell carcinomas (HNSCC) are treated by surgery or radiotherapy. Tumor cell death-related markers, such as p21 and Ki-67, may predict response to therapy and improve treatment choice. We evaluated and compared the effect of their coexpression between patients treated by surgery or radiotherapy.

Methods. Immunohistochemistry for p21 and Ki-67 expression in 144 pharyngeal and laryngeal HNSCC samples was analyzed and correlated with follow-up parameters.

Results. p21 expression correlated significantly with positive cN classification (p < .001), locoregional relapse (p ¼ .031), and poor overall survival (p ¼ .016), and Ki-67 positivity with poor survival only (p ¼ .025). Coexpressing tumor phenotypes showed the worst survival (p ¼ .009), observed primarily in patients treated by radiotherapy (p ¼ .077).

Conclusions. Coexpression of p21/Ki-67 is a strong negative prognostic factor in HNSCC and could be of particular relevance in tumors treated by primary radiotherapy. V

📜 SIMILAR VOLUMES

A Phase I/II trial of concurrent docetax

A Phase I/II trial of concurrent docetaxel and radiation after induction chemotherapy in patients with poor prognosis squamous cell carcinoma of the head and neck

✍ Roy B. Tishler; Charles M. Norris Jr.; A. Dimitrios Colevas; Carolyn C. Lamb; Da 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 95 KB 👁 1 views

## Abstract ## BACKGROUND The authors conducted a Phase I/II study in patients with a poor prognosis who had locally advanced squamous cell carcinoma of the head and neck (SCCHN) and who were treated initially with induction chemotherapy. Patients were treated with weekly docetaxel and concurrent

A subset of head and neck squamous cell

A subset of head and neck squamous cell carcinomas exhibits integration of HPV 16/18 DNA and overexpression of p16INK4A and p53 in the absence of mutations in p53 exons 5–8

✍ Harriet C. Hafkamp; Ernst J.M. Speel; Annick Haesevoets; Fredrik J. Bot; Winand 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 188 KB 👁 1 views

## Abstract Besides well‐known risk factors such as tobacco use and alcohol consumption, oncogenic human papillomavirus (HPV) infection also has recently been suggested to promote head and neck tumorigenesis. HPV is known to cause cancer by inactivation of cell cycle regulators p53 and pRb via expr

Association of p73 G4C14-to-A4T14 polymo

Association of p73 G4C14-to-A4T14 polymorphism with human papillomavirus type 16 status in squamous cell carcinoma of the head and neck in non-Hispanic whites

✍ Xuemei Ji; Erich M. Sturgis; Chong Zhao; Carol J. Etzel; Qingyi Wei; Guojun Li 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 156 KB 👁 1 views

## Abstract ## BACKGROUND: The tumor protein p73 interacts with the human papillomavirus type 16 (HPV‐16) oncoproteins E6 and E7, and __p73__ variation may modify the interaction between p73 protein and HPV‐16 oncogenic proteins and contribute to cellular malignant transformation. ## METHODS: In