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Co-operativity of hexamer ligation

โœ Scribed by Tadeusz Kaczorowski; Waclaw Szybalski

Book ID
117521796
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
659 KB
Volume
179
Category
Article
ISSN
0378-1119

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A method is described for the ordered ligation of hexanucleotides (hexamers) in solution to produce unique longer oligonucleotides. To form an 18-mer, for example, six different hexamers are selected that can base pair unambiguously to form a double-stranded complex of indefinite length. In the most