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Co-occurrence of restless legs syndrome and Parkin mutations in two families

✍ Scribed by Susanna Adel; Ana Djarmati; Kemal Kabakci; Irene Pichler; Cordula Eskelson; Thora Lohnau; Norman Kock; Johann Hagenah; Katja Hedrich; Eberhard Schwinger; Patricia L. Kramer; Peter P. Pramstaller; Christine Klein

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
158 KB
Volume
21
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

Recent studies have suggested an association between restless legs syndrome (RLS) and Parkinson's disease (PD). We present a large multigenerational family and a smaller family with RLS. A Parkin mutation was found in 10 of 20 patients from both families with idiopathic RLS but was not considered causative. The clinical phenotype did not differ between RLS patients with and without a Parkin mutation. Inheritance of RLS was consistent with autosomal dominant transmission, and linkage analysis excluded all three known loci for RLS. Β© 2005 Movement Disorder Society

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