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CO migration pathways in cytochrome P450cam studied by molecular dynamics simulations

✍ Scribed by Liliane Mouawad; Catherine Tetreau; Safwat Abdel-Azeim; David Perahia; Daniel Lavalette

Book ID
111752807
Publisher
Cold Spring Harbor Laboratory Press
Year
2007
Tongue
English
Weight
811 KB
Volume
16
Category
Article
ISSN
0961-8368

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## Abstract The kinetic analysis of coumarin oxidation by CYP2A6 suggested that substrate binding and release occurred in the multiple steps and such events proceeded rapidly. However, the crystal structure of the CYP2A6‐coumarin complex reveals that no obvious channel is open enough to allow couma