## Abstract Hereditary cerebral hemorrhage with amyloidosis, Dutch type (HCHWA‐D), is an autosomal dominant disorder caused by the Dutch mutation (E693Q) in the β‐amyloid precursor protein. This mutation produces an aberrant amyloid β (Aβ) species (AβE22Q) and causes severe meningocortical vascular
✦ LIBER ✦
Co-localization of β/A4 and cystatin C in cortical blood vessels in Dutch, but not in Icelandic hereditary cerebral hemorrhage with amyloidosis
✍ Scribed by J. Haan; M. L. C. Maat-Schieman; S. G. van Duinen; O. Jensson; L. Thorsteinsson; R. A. C. Roos
- Book ID
- 114784137
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 552 KB
- Volume
- 89
- Category
- Article
- ISSN
- 0001-6314
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## Abstract The amyloid β‐protein is a 39‐42 amino acid peptide that is deposited in senile plaques and in cerebral vessel walls in individuals with Alzheimer's disease, Down's syndrome, hereditary cerebral hemorrhage with amyloidosis–Dutch type (HCHW A‐D), and, to a much lesser extent, normal agin