✦ LIBER ✦

Co-localization of differentially expressed genes and shared susceptibility loci in human autoimmunity

✍ Scribed by Thomas M. Aune; Joel S. Parker; Kevin Maas; Zheng Liu; Nancy J. Olsen; Jason H. Moore

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 259 KB
Volume: 27
Category: Article
ISSN: 0741-0395
DOI: 10.1002/gepi.20013

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Autoimmune diseases arise from complex interactions between environmental and genetic factors. Genetic linkage scans show that different autoimmune diseases share overlapping susceptibility loci. Lymphocytes from individuals with different autoimmune diseases, as well as unaffected first‐degree relatives, also share a common gene expression profile. We sought to determine if genes within this autoimmune expression profile were nonrandomly distributed in the genome and if their distribution overlapped with shared disease susceptibility loci. We found that differentially expressed genes were distributed in a nonrandom fashion in chromosomal domains within the genome. Furthermore, positions of these domains were not statistically different from a number of shared autoimmune disease susceptibility loci. To our knowledge, this is the first study showing concordance between gene expression and genetic linkage results in common complex multifactorial human diseases. © 2004 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Isolation of genes differentially expres

Isolation of genes differentially expressed in human primary myoblasts and embryonal rhabdomyosarcoma

✍ Michele Genini; Petra Schwalbe; Florence A. Scholl; Beat W. Schäfer 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 842 KB

Using a subtractive hybridization method, we have cloned 48 cDNAs which are expressed in human primary myoblasts but down-regulated in the embryonal-rhabdomyosarcoma (RMS) cell line RD. Twenty-nine sequences could be identified as coding for previously known gene products, while 19 encode unknown pr

Identification of genes differentially e

Identification of genes differentially expressed in human hepatocellular carcinoma by a modified suppression subtractive hybridization method

✍ Xue-Yuan Dong; Xue-Wen Pang; Song-Tao Yu; Yan-Rong Su; Hong-Chen Wang; Yan-Hui Y 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 314 KB 👁 1 views

## Abstract To identify differentially expressed genes in human HCC in China, we applied a modified SSH method for cDNA subtraction. Such modification has made the method more effective for subtraction. We have obtained 36 and 24 differentially expressed cDNA fragments after modified SSH from 4 pai

Identification of differentially express

Identification of differentially expressed genes in human melanoma cells with acquired resistance to various antineoplastic drugs

✍ Claudia Grottke; Klaus Mantwill; Manfred Dietel; Dirk Schadendorf; Hermann Lage 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 608 KB

Microarray analyses of differentially ex

Microarray analyses of differentially expressed human genes and biological processes in ECV304 cells infected with rubella virus

✍ Xiao-yang Mo; Wenli Ma; Yali Zhang; Haiquan Zhao; Yun Deng; Wuzhou Yuan; Yuequn 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 132 KB

## Abstract Changes in mRNA expression levels of ECV304 cells infected with the wild‐type rubella strain were analyzed using a microarray system representing 18,716 human genes. Four hundred eighty‐seven genes exhibited differential expression levels; 456 of these genes were up‐regulated while 31 g

Localization and expression of the human

Localization and expression of the human estrogen receptor beta gene in uterine leiomyomata

✍ Florence Pedeutour; Bradley J. Quade; Stanislawa Weremowicz; Paola Dal Cin; Sima 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 147 KB 👁 2 views

Estrogens have an important function in the natural history of uterine leiomyomata. The human estrogen receptor beta gene (ESR2) has been identified recently and mapped to 14q22-24, a region frequently rearranged in uterine leiomyomata and other benign tumors, including pulmonary chondroid hamartoma

Differential desensitization of lipopoly

Differential desensitization of lipopolysaccharide-inducible chemokine gene expression in human monocytes and macrophages

✍ Andreas Kaufmann; Diethard Gemsa; Hans Sprenger 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 142 KB 👁 2 views

Bacterial lipopolysaccharide (LPS) has been shown to induce a wide variety of proinflammatory cytokines and chemokines. An initial challenge with minute amounts of LPS causes tolerance to later LPS effects which is characterized by a much lower or abrogated release of pro-inflammatory cytokines. To