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Co-amplification of theHER2gene and chromosome 17 centromere: a potential diagnostic pitfall in HER2 testing in breast cancer

✍ Scribed by Zsuzsanna Varga; Raymond R. Tubbs; Zhen Wang; Yang Sun; Aurelia Noske; Doris Kradolfer; Giovanna Bosshard; Wolfram Jochum; Holger Moch; Christian Öhlschlegel


Book ID
113062277
Publisher
Springer US
Year
2011
Tongue
English
Weight
502 KB
Volume
132
Category
Article
ISSN
0167-6806

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Loss of heterozygosity at chromosome 17p
✍ Evgeny N. Imyanitov; Oleg I. Chernitsa; Irina F. Nikiforova 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 French ⚖ 703 KB

## Abstract Sixty DNA samples from breast carcinoma (BC) patients were analyzed by Southern blot to examine certain oncogene and anti‐oncogene alterations. Amplification of the HER‐2 oncogene was detected in 15 tumours (25%), c‐myc in 2 (3%) only and HER‐1 in none. Distribution of Hras‐1 oncogene a