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CNI-1493 mediated suppression of dendritic cell activation in vitro and in vivo

✍ Scribed by Elisabeth Zinser; Nadine Turza; Alexander Steinkasserer

Book ID
116569007
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
311 KB
Volume
209
Category
Article
ISSN
0171-2985

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## Abstract CD4^+^CD25^+^ regulatory T cells (Tregs) are critical for peripheral tolerance and prevention of autoimmunity. __In vitro__ coculture studies have revealed that increased costimulation breaks Treg‐mediated suppression in response to anti‐CD3 or antigen. However, it was unclear whether l