CMR 2007: 8.03: Gold nanoparticles as contrast agents for MRI and X-ray computed tomography imaging
✍ Scribed by S. Roux; C. Alric; J. Taleb; C. Mandon; C. Billotey; T. Brochard; G. Le Duc; P.-J. Debouttière; F. Vocanson; M. Janier; P. Perriat; O. Tillement
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 68 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1555-4309
- DOI
- 10.1002/cmmi.195
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✦ Synopsis
small size of the hybrid particles ( < 10 nm) and to the presence of PEG chains tethered to the particles. On the other hand, these particles can be internalized by different cell types (macrophages, fibroblasts, lymphocytes, etc.). As a result, the labeled cells can be visualized by MRI and fluorescence imaging. If the metabolic activity of the cells is almost not affected by the presence of the hybrid particles, cells after internalization of the particles were killed when submitted to a thermal neutron beam, whereas its innocuousness was attested. This experiment reveals consequently the therapeutic potential of gadolinium oxide nanoparticles for cancer therapy by neutron capture. Gadolinium oxide nanoparticles embedded in a pegylated and luminescent polysiloxane shell are very attractive since they are well suited for in vivo dual modality magnetic resonance and fluorescence imaging and they induce cell death after neutron capture. These particles are expected to combine diagnosis and cancer therapy.