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CMR 2005: 9.02: Detection of single cells by high-field MRI

✍ Scribed by F. Gazeau; P. Smirnov; J.P. Fortin; C. Wilhelm; B. Gillet

Book ID
102105432
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
42 KB
Volume
1
Category
Article
ISSN
1555-4309

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✦ Synopsis

aneurysm sac, were obtained. Using the Doppler mode, the flow velocities in the afferent and the downstream vascular segments and also inside the aneurysm were recorded and assessed. Further, single UCA microbubbles in the aneurysm sac could be visualized. This enabled us to visualize in real-time the flow dynamics for the first time in vivo. We measured the spatial and temporal distribution of the velocity in the aneurysm and in the parent vessel using backscattered signals from UCA microbubbles. Subsequently, standard computational flowdynamic (CFD) DPIV codes were used to calculate the fluid stresses, vorticity, circulation, etc., from the velocity measurements. The measurements showed that the flow inside the aneurismal sac is dominated by the presence of a large three-dimensional vortex. Although the circulation (integral of the vorticity flux over the crosssection) is maximum at peak systole, the rotational motion persists throughout the whole cardiac cycle, indicating that the flow shear exerted on the dome never vanishes.

Conclusion:

The present in vivo technique allows one for the first time to measure real-time the specific flow features associated with intracranial aneurysms and opens a new and valuable avenue to study the flow features which may be responsible for the enlargement rate and the eventual rupture of the aneurysm. Moreover, the information obtained with the technique described may be used to validate experimental in vitro studies existing in the literature

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