CMR 2005: 6.04: Blood-pool contrast medium (Vistarem) discriminates acutely infarcted from scarred myocardium on late enhancement
✍ Scribed by M. Saeed; O. Weber; R. Lee; L. Do; P. Robert; C. Corot; D. Saloner; C.B. Higgins
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 47 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1555-4309
- DOI
- 10.1002/cmmi.37
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✦ Synopsis
demonstrated central necrosis on imaging being those with both the greatest and least difference between agents. The lesion contrast-to-noise ratio (as assessed by the signal intensity of the lesion post-contrast minus that of normal brain post-contrast over noise) was on average 35 AE 9% greater with gadobenate dimeglumine than gadopentetate dimeglumine (P ¼ 0.002). Examining specifically the change in contrast agent effect with field strength, lesion enhancement with gadobenate dimeglumine was 113 AE 32% (P ¼ 0.0003) greater at 3 T than 1.5 Tand lesion contrastto-noise ratio 120 AE 24% (P ¼ 0.0001) greater, respectively. Conclusion: Despite changes in T 1 relaxivity inherent with the increase in field strength from 1.5 T, gadobenate dimeglumine continues to demonstrate at 3 T a significant improvement in lesion contrast enhancement (44%) compared with conventional extracellular gadolinium chelates and more specifically gadopentetate dimeglumine. The improvement in enhancement effect is similar to that seen at 1.5 Twhen comparing these agents. Also noted is an improvement in contrast effect overall on changing from a field of 1.5 to 3 T, with a significant and substantial increase (113%) demonstrated with gadobenate dimeglumine.