CMR 2005: 1.04: Comparison of VSOP-C184, gadopentetate dimeglumine and ferucarbotran in T1-weighted dynamic and T2-weighted late MRI of focal liver lesions in rabbits
✍ Scribed by J. Schnorr; S. Wagner; C. Abramjuk; T. Schink; E. Schellenberger; H. Pilgrimm; B. Hamm; M. Taupitz
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 81 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1555-4309
- DOI
- 10.1002/cmmi.5
No coin nor oath required. For personal study only.
✦ Synopsis
Results: Figure 1(A) shows that $10% of injected AMNP reside in bile samples and the percentage decreases over time. The TEM image in Fig. 1(B) confirms the presence of AMNP in bile samples collected at 15 min. Fe concentrations in blood samples were obtained (eg. [Fe] at 17 min after i.v. injection ¼ 4.43Â10 À6 M) and the remnance curve shows biexponential decay (t ¼ 5.6 and 289 min). Conclusion: This study demonstrated hepatobiliary elimination of AMNP. Ongoing studies in quantification of urinary elimination would allow a complete understanding of AMNP biodistribution. Non-specific uptake of AMNP by RES is low, making AMNP particularly useful in cell-specific targeting when conjugated with effectors, opening the way to efficient, targeting MR imaging. CMR 2005: 1.04 Comparison of VSOP-C184, gadopentetate dimeglumine and ferucarbotran in T1-weighted dynamic and T 2 -weighted late MRI of focal liver lesions in rabbits