Clustering of hepatocellular carcinoma in Alaska Native families

✍ Scribed by Steven R. Alberts; Dr. Anne P. Lanier; Brian J. McMahon; Annette Harpster; Lisa R. Bulkow; William L. Heyward; Christine Murray; G. P. Vogler

• Book ID: 102844975
• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 792 KB
• Volume: 8
• Category: Article
• ISSN: 0741-0395
• DOI: 10.1002/gepi.1370080206

✦ Synopsis

Alaska Natives have a high incidence of hepatocellular carcinoma (HCC), with regional, ethnic, village, and familial clustering. During 1969-1988, 15 of the 45 incident cases of HCC in Alaska Natives occurred in 5 families. This report presents epidemiologic, virologic, and immunogenetic data on these 5 families. The results of hepatitis B virus (HBV) serologic testing indicates that HBV infection was an important factor in 4 of the 5 families. Human lymphocyte antigen (HLA) testing was performed in 3 families. The HLA results are reviewed in relationship to the familial clustering of HCC.