Clustering of Fournier (male genital) gangrene cases in a pediatric cancer ward
✍ Scribed by Bakshi, Chetna ;Banavali, Shripad ;Lokeshwar, Nilesh ;Prasad, Rajendra ;Advani, Suresh
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 93 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0098-1532
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✦ Synopsis
majority of secondary Burkitt ALL/BL were patients previously treated with combined modality therapy. Ikeda et al.
[10] reported a patient with myelodysplastic syndrome that transformed to Burkitt ALL. The patient had a past history of laryngeal carcinoma treated with local irradiation and chemotherapy. Thus, taking the unusual clinical manifestation in our case into consideration, it is likely that chemo-radiotherapy including high-dose chemotherapy for primary rhabdomyosar-coma may have contributed to the development of Burkitt ALL. However, genetic susceptibility must be considered as well, because germline p53 mutations have been frequently detected in young children with rhabdomyosarcoma [11]. The respective contributions of prior therapy, genetics, or random chance, to the development of secondary ALL including Burkitt leukemia should be determined through a large cohort study.