The reciprocal translocation t(1;3)(p36;q21) is associated with myelodysplastic syndromes (MDSs) and acute myeloid leukemia (AML) characterized by trilineage dysplasia, in particular dysmegakaryocytopoiesis, and a poor prognosis. As yet no molecular genetic analyses of the t(1;3) have been reported.
Clustering of 1p36 breakpoints distal to 1p36.2 in hematological malignancies
β Scribed by A.E Varga; A Dobrovic; G.C Webb; R Hutchinson
- Book ID
- 114135003
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 29 KB
- Volume
- 125
- Category
- Article
- ISSN
- 0165-4608
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## Abstract Recently, we reported that a recurrent translocation, t(1;3)(p36;p21) is closely associated with prior chemotherapy including alkylating agents, assessing eight patients with various hematologic malignancies (Genes, Chromosomes and Cancer 34:186β192), 2002). Furthermore, we delineated t