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Clusterin, a novel modulator of TGF-β signaling, is involved in Smad2/3 stability

✍ Scribed by Kwan-Bok Lee; Jun-Ho Jeon; Inpyo Choi; O-Yu Kwon; Kweon Yu; Kwan-Hee You

Book ID
116296121
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
210 KB
Volume
366
Category
Article
ISSN
0006-291X

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## Abstract Transforming growth factor‐beta (TGF‐β) is an important growth inhibitor of epithelial cells, and insensitivity to this cytokine results in uncontrolled cell proliferation and can contribute to tumorigenesis. Smad2 and Smad3 are direct mediators of TGF‐β signaling, however little is kno