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Clozapine for psychosis in Parkinson's disease

✍ Scribed by Dr. Ronald F. Pfeiffer; Jasbir Kang; Benjamin Graber; Ruth Hofman; James Wilson

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 321 KB
Volume: 5
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.870050310

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The clinical efficacy of clozapine, an atypical antipsychotic, in treating levodopa‐induced hallucinations was investigated in five patients with Parkinson's disease under open label conditions. Two patients could not tolerate clozapine, even in doses as low as 12.5–25 mg daily, because of extreme sedation. Three patients could tolerate clozapine and experienced improvement or elimination of their hallucinations at doses below 100 mg daily. Despite a significant risk of adverse effects, cautious use of clozapine in low doses may be beneficial for patients with levodopa‐induced psychosis who do not respond to more conservative measures.

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