✍ Scribed by Alexandros Kiparissides; Michalis Koutinas; Cleo Kontoravdi; Athanasios Mantalaris; Efstratios N. Pistikopoulos
No coin nor oath required. For personal study only.
This work presents a holistic 'closed loop' approach for the development of models of biological systems. The ever-increasing availability of experimental information necessitates the advancement of a systematic methodology to organise and utilise these data. Herein, we present a biological model building framework that maps the treatment of the information from the initial conception of the model, through its experimental validation and finally to its application in model-based optimisation studies. We highlight and discuss current issues associated with the development of mathematical models of biological systems and share our perspective towards a holistic 'closed loop' approach that will facilitate the control of the in vitro through the in silico.
📜 SIMILAR VOLUMES
AbstractwAn analytical procedure for the sensitivity analysis of the pole spectrum in a feedback control system is presented. The procedure applies to the sensitivity investigations of system closed-loop poles due to variations of controller and/or plant parameters. Suitable defined sensitivities an