CLOSE LINKAGE OF HYPERVARIABLE MARKER DXS255 TO DISEASE LOCUS OF WISKOTT-ALDRICH SYNDROME
โ Scribed by Basile, G.deSaint; Fraser, N.J.; Craig, I.W.; Arveiler, B.; Boyd, Y.; Griscelli, G.; Fischer, A.
- Book ID
- 122499384
- Publisher
- The Lancet
- Year
- 1989
- Tongue
- English
- Weight
- 419 KB
- Volume
- 334
- Category
- Article
- ISSN
- 0140-6736
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The Wiskott-Aldrich syndrome (WAS) has previously been mapped to the proximal short arm of the X chromosome between the DXS14 and DXS7 loci. In this study, further segregation analysis has been performed using a newly identified WAS family as well as an additional marker probe, HOATL1. The results i
Linkage analysis was performed in 19 families segregating for the Wiskott-Aldrich syndrome (WAS) and in 1 family with X-linked thrombocytopenia using nine polymorphic DNA markers spanning the interval DXS7-DXS14. The results confirm close linkage of WAS to the DXS7, TIMP, OATL1, DXS255, DXS146, and