Close linkage between X-linked ectodermal dysplasia and a cloned DNA sequence detecting a two allele restriction fragment length polymorphism in the region Xp11-q12
✍ Scribed by Steen Kølvraa; Torben A. Kruse; P. K. A. Jensen; Kirsten H. Linde; Søren R. Vestergaard; Lars Bolund
- Publisher
- Springer
- Year
- 1986
- Tongue
- English
- Weight
- 382 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0340-6717
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✦ Synopsis
EDA (ectodermal dysplasia, anhidrotic) is an X-linked recessive disorder characterized by hypohidrosis, hypoor anodontia, and hypotrichosis. A possible linkage between the gene for EDA and a number of restriction fragment length polymorphisms (RFLPs) spread over the X chromosome was investigated in two Danish families segregating EDA. No recombination between the gene for EDA and our probe pTAK8, which detects a two allele polymorphism in the region Xp11-q12, was found in nine informative meiotic events (seven of which are phase known), giving a maximal lod score of 2.41 at a recombination fraction of 0.00. This juxtacentromeric location of the gene for EDA agrees well with the linkage data obtained with the other markers used in this study.