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CLOSE GENETIC LINKAGE BETWEEN DIABETES MELLITUS AND KIDD BLOOD GROUP

โœ Scribed by Hodge, SusanE; Neiswanger, Katherine; Anne Spence, M; Sparkes, MaryellenC; Terasaki, PaulI; Anderson, CarolE; Leigh Field, L; Sparkes, RobertS; Crist, Michol; Rimoin, DavidL

Book ID
122795364
Publisher
The Lancet
Year
1981
Tongue
English
Weight
471 KB
Volume
318
Category
Article
ISSN
0140-6736

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โœฆ Synopsis

27 polymorphic genetic markers were analysed for possible linkage with insulin-dependent diabetes mellitus (IDDM). The data set contained 71 families with at least one affected member each. Under three different genetic models for IDDM, evidence was found for linkage between the disease and two distinct sets of marker loci: three markers on chromosome 6 (HLA, properdin factor B, and glyoxalase-1), and the Kidd blood group locus. The families apparently do not fall into two groups, one exhibiting linkage to the HLA complex and the other to the Kidd locus. Thus, two distinct disease-susceptibility loci may be involved in the inheritance of IDDM.

๐Ÿ“œ SIMILAR VOLUMES

Association studies between type 1 (insu
Association studies between type 1 (insulin-dependent) diabetes and 27 genetic markers: Lack of association between type 1 diabetes and kidd blood group
โœ S. E. Hodge; C. E. Anderson; K. Neiswanger; R. Rubin; R. S. Sparkes; M. C. Spark ๐Ÿ“‚ Article ๐Ÿ“… 1983 ๐Ÿ› Springer ๐ŸŒ English โš– 560 KB

One hundred and three unrelated patients with Type 1 (insulin-dependent) diabetes were typed for HLA, properdin factor B (BF), glyoxalase 1 (GLO), Kidd blood group, and 24 other genetic markers. Observed distributions of marker phenotypes among these patients were compared with those expected accord