To the Editor: Idiopathic thrombotic thrombocytopenic purpura (TTP) is a lifethreatening disease characterized by thrombocytopenia, microangiopathic hemolytic anemia, fever, neurologic changes, and renal dysfunction and is related to autoantibodies against von Willebrand factor cleaving metalloprote
Clopidogrel-associated autoimmune thrombocytopenic purpura
β Scribed by Patricia J.M. Best; Verghese Mathew; Svetomir N. Markovic
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 38 KB
- Volume
- 62
- Category
- Article
- ISSN
- 1522-1946
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β¦ Synopsis
Abstract
We report the case of a 51βyearβold male who underwent coronary stent placement for the treatment of an acute myocardial infarction. One week later, he developed symptomatic autoimmune thrombocytopenia likely related to clopidogrel use. This was successfully treated with intravenous methylprednisilone and platelet transfusions. Catheter Cardiovasc Interv 2004;62:339β340. Β© 2004 WileyβLiss, Inc.
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Twenty-one human immunodeficiency virus (HIV)-free and six HIV-infected adults with autoimmune thrombocytopenic purpura (AITP) were treated with dapsone (100 mg/day). A response was observed in 13 patients (median platelet count before 25 x 109/L, range 3-49; after 109 x 10g/L, range 69-241). Thromb
levels were not different from normal subjects statistically (Table ). No significant correlations were noted between the platelet counts and serum cytokine concentrations.