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Cloning of the TIS gene suppressed by topoisomerase inhibitors

โœ Scribed by Yoshiaki Onishi; Sadamitsu Hashimoto; Harutoshi Kizaki


Book ID
117523217
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
432 KB
Volume
215
Category
Article
ISSN
0378-1119

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We examined the effects of the introduction of H-ras oncogene into murine cell line NIH3T3 on growth inhibition by topoisomerase-I (topo-I) inhibitors. The H-ras-transformed cells (pT22-3) showed approximately I 2-fold increased sensitivity to a novel topo-l inhibitor, NB-506 [6-N-formylamino-I2,I3d