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Cloning of the guinea pig αENaC, a subunit of the epithelial sodium channel, and analysis of its sequence and expression in the organ of corti

✍ Scribed by Anand N. Mhatre; Anil K. Lalwani; Geoff M. Duyk


Book ID
117400870
Publisher
SAGE Publications
Year
1995
Tongue
English
Weight
118 KB
Volume
113
Category
Article
ISSN
0194-5998

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Actions of dolasetron and its major meta
✍ Robert Dumaine; Hali A. Hartmann; Derek J. Leishman; Arthur M. Brown; Martin Gal 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 695 KB

The present study evaluated the effects of the anti-emetic 5-HT3 antagonist dolasetron and its major metabolite MDL 73,405 on guinea-pig papillary muscle fibres and human heart sodium channels expressed in Xenopus oocytes. Dolasetron and MDL 73,405 (3-10 p M ) reduced the maximum depolarization rate