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Cloning and sequence analysis of a zebrafish cDNA encoding DNA (cytosine-5)-methyltransferase-1

✍ Scribed by Aizeddin A. Mhanni; Jeffrey A. Yoder; Christa Dubesky; Ross A. McGowan

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 526 KB
Volume: 30
Category: Article
ISSN: 1526-954X
DOI: 10.1002/gene.1067

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✦ Synopsis

The zebrafish has become a well-established animal model for the analysis of development and of several disease phenotypes. Several of the favorable traits that make it a popular model organism would also be beneficial for the study of normal and abnormal vertebrate development in which DNA methylation may play a role. We report the determination of the full-length cDNA sequence corresponding to the zebrafish DNA (cytosine-5-) methyltransferase gene, Dnmt1. It is 4,907 bases long and has an open reading frame predicted to encode a 1,499 amino acid protein that is similar in size and sequence to a number of other methyltransferases identified in other organisms.

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