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Cloning and molecular characterization of human high affinity antibody fragments against Hepatitis C virus NS3 helicase

✍ Scribed by Kathi Tessmann; Andreas Erhardt; Dieter Häussinger; Tobias Heintges


Book ID
114139841
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
830 KB
Volume
103
Category
Article
ISSN
0166-0934

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Demonstration of antibodies inhibiting key viral functions is the basis for the design of an effective vaccine. Dissection of the human antibody response by repertoire cloning may be a powerful means to address this issue. In this study, a panel of human monoclonal recombinant Fab fragments specific