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Cloning and expression of human liver UDP-glucuronosyltransferase cDNA, UDPGTh2

โœ Scribed by Misook Dong; Ida S. Owens; Yhun Yhong Sheen

Publisher
Springer
Year
1997
Tongue
English
Weight
708 KB
Volume
20
Category
Article
ISSN
0253-6269

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Glucuronidation of olanzapine by cDNA-ex
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โœ Kristian Linnet ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 72 KB

Olanzapine is a widely used, newer antipsychotic agent, which is metabolized by various pathways: hydroxylation and N-demethylation by cytochrome P450, N-oxidation by flavin monooxygenase and direct glucuronidation. In vivo studies have pointed towards the latter pathway as being of major importance