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Cloning and expression of cDNA of human Δ4-3-oxosteroid 5β-reductase and substrate specificity of the expressed enzyme

✍ Scribed by Kazu-Hiro KONDO; Masa-Hiro KAI; Yoshiko SETOGUCHI; Gösta EGGERTSEN; Peter SJÖBLOM; Toshiaki SETOGUCHI; Kyu-Ichiro OKUDA; Ingemar BJÖRKHEM


Book ID
115130998
Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
801 KB
Volume
219
Category
Article
ISSN
1432-1327

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The 3__β__‐hydroxysteroid dehydrogenase/__Δ__5‐__Δ__4‐isomerase (3__β__‐HSD) enzymes are essential for the biosynthesis of steroid hormones. The 3__β__‐HSD gene family has been reported to encode for different isoenzymes which function either as dehydrogenase/isomerase or as reductase. The 3__β__‐HS