Somatic mutations are hallmarks of cancer progression. We sequenced 26 matched human prostate tumor and constitutional DNA samples for somatic alterations in the SRD5A2, HPRT, and HSD3B2 genes, and identified 71 nucleotide substitutions. Of these substitutions, 79% (56/71) occur within a WKVnRRRnVWK
β¦ LIBER β¦
Cloned mouse lymphocytes permit analysis of somatic mutations that occur in vivo
β Scribed by Irene M. Jones; Karolyn Burkhart-Schultz; Tawni L. Crippen
- Book ID
- 112557802
- Publisher
- Springer
- Year
- 1987
- Tongue
- English
- Weight
- 895 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1572-9931
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The endogenous, autosomal Tk gene is a potentially useful reporter of in vivo mutation since it may recover a wider range of mutational events than the X-linked Hprt gene or bacterial transgenes. In this study, we characterized mutations produced in the Tk gene of Tk Ο©/Οͺ mice and compared them with