## Abstract ## BACKGROUND Lobular carcinoma in situ (LCIS) of the breast is considered a marker for an increased risk of carcinoma in both breasts. However, the frequent association of LCIS with invasive lobular carcinoma (ILC) suggests a precursorβproduct relation. The possible genomic relation b
Clonality of lobular carcinoma in situ (LCIS) and metachronous invasive breast cancer
β Scribed by Sebastian Aulmann; Roland Penzel; Thomas Longerich; Benjamin Funke; Peter Schirmacher; Hans Peter Sinn
- Publisher
- Springer US
- Year
- 2007
- Tongue
- English
- Weight
- 130 KB
- Volume
- 107
- Category
- Article
- ISSN
- 0167-6806
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## Loss of expression of the intercellular adhesion molecule E-cadherin frequently occurs in invasive lobular breast carcinomas as a result of mutational inactivation. Expression patterns of E-cadherin and the molecules comprising the cytoplasmic complex of adherens junctions, -, -and -catenin, we
Lobular carcinoma in situ (LCIS) of the breast is commonly identified as an incidental finding in breast biopsies performed because of either a mammographic abnormality or a palpable mass. Although long recognized as an entity, the significance and optimal treatment of LCIS remains controversial. In