Clonal trisomy 8 is associated with myeloid phenotype rather than the neoplastic transformation in acute leukemia
✍ Scribed by William F. Cassano; Marilyn S. Hintz
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 573 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0361-8609
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✦ Synopsis
Our studies of an acute leukemia with a clonal t(1;ll) marker have demonstrated a conversion from p r e d cell to myelomonocytic phenotype associated with the acquisltion of trisomy 8. This finding suggests that trisomy 8, a frequent clonal abnormality in acute myelold leukemias, may be associated with the myelold phenotype rather than the neoplastic transformation. A permanent myelomonocytic cell line, designated UF-SK1 , has been established from leukemic cells with a 47,XX, +8,t(1;11) (p31 ;q25) karyotype and shown to have myelomonocytic characterlstics, Including phorbol ester-induced differentiation to macrophages. This new cell line will be a valuable tool In the study of leukemogenesis and lineage commitment.