The major obstacle preventing effective treatment of melanoma is the biological heterogeneity of tumor cells. This study was performed to determine clonal genetic heterogeneity within primary melanoma and the evolution of these heterogeneous sub-clones during disease progression. DNA samples were ob
Clonal selection of adenocarcinoma of the lung as determined by loss of heterozygosity
โ Scribed by Sanja Dacic; Sydney D. Finkelstein; Samuel A. Yousem
- Book ID
- 113956338
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 182 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0014-4800
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An allelotype analysis of lung tumors in mouse hybrids was conducted to identify common regions of allelic loss. By using 50 informative genetic markers, the autosomes of 36 (NJ x C3HIHeJ) F, adenocarcinomas were examined. Additional adenocarcinomas from as many as 72 (C3H/HeJ x NJ) F, and 15 (BALBl