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Clonal selection drives genetic divergence of metastatic medulloblastoma

✍ Scribed by Wu, Xiaochong; Northcott, Paul A.; Dubuc, Adrian; Dupuy, Adam J.; Shih, David J. H.; Witt, Hendrik; Croul, Sidney; Bouffet, Eric; Fults, Daniel W.; Eberhart, Charles G.


Book ID
111649875
Publisher
Nature Publishing Group
Year
2012
Tongue
English
Weight
926 KB
Volume
482
Category
Article
ISSN
0028-0836

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## Abstract Our previous studies using randomly integrated plasmid DNA as unique clonotypic markers of SP1 mouse mammary tumor cells transplanted into syngeneic CBA/J or nude mice demonstrated reproducible selection and eventual overgrowth of the primary transplant tumors by genotypically distinct