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Clonal immunoglobulin gene rearrangements in chronic lymphocytic leukemia: A correlative study

✍ Scribed by L. Soper; B. Bernhardt; A. Eisenberg; B. Cacciapaglia; L. Bennett; A. Sanda; M. Baird; R. Silver; P. Benn


Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
935 KB
Volume
27
Category
Article
ISSN
0361-8609

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## Abstract Chronic lymphocytic leukemia (CLL) cells are characterized by several chromosomal lesions. Some of these aberrations imply chromosome breaks as a result of unrepaired double strand breaks (DSBs) in the DNA. The ATM (ataxia telangiectasia‐mutated) protein is the principal integrator of c