✦ LIBER ✦

Clonal extinction of myelomonocytic leukemic cells by serum from mice injected with endotoxin

✍ Scribed by D. Metcalf

Publisher: John Wiley and Sons
Year: 1980
Tongue: French
Weight: 826 KB
Volume: 25
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910250210

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✦ Synopsis

Abstract

Culture of WEHI‐3B myelomonocytic leukemic cells in semi‐solid agar medium containing post‐endotoxin serum led to the development of maturing granulocytes and macrophages in most leukemic colonies. Colony size was consistently increased but the colony content of colony‐forming cells (stem‐cell self‐replication) was markedly reduced. Serial recloning of WEHI‐3B colony cells in the continuous presence of post‐endotoxin serum led to clonal extinction of the leukemic cells in five of seven experiments. These effects of post‐endotoxin serum on WEHI‐3B cells were not seen in clonal cultures of 10 other tumor lines. Serum with the capacity to induce differentiation in WEHI‐3B cells could be induced by the injection of as little as 0.1 μg endotoxin and by purified bacterial cell‐wall preparations. Serum activity reached peak levels 3 – 6 h after endotoxin injection and returned to preinjection levels within 48 h.

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