Clonal chromosome abnormalities in human breast carcinomas II. Thirty-four cases with metastatic disease

✍ Scribed by Jeffrey Trent; Jin-Ming Yang; Julia Emerson; William Dalton; Daniel McGee; Kathy Massey; Floyd Thompson; Hugo Villar

• Book ID: 102845473
• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 677 KB
• Volume: 7
• Category: Article
• ISSN: 1045-2257
• DOI: 10.1002/gcc.2870070403

✦ Synopsis

Cytogenetic analysis was performed on a selected series of short-term cultures from 34 patients with documented metastatic breast carcinoma. The majority of tumor cells were hyperdiploid, with clonal structural alterations observed in 94% of patients (32/34). The most common numeric changes were -2, -15, and -18. Chromosome 20 was the most frequently overrepresented (in near-3n tumors only). Clonal structural chromosome alterations included isochromosomes, terminal deletions, and, most frequently, unbalanced non-reciprocal translocations. Chromosomes most often involved in structural rearrangements included I, 7, I I, and 6 (accounting for 24.7%, 10.3%, 9.l%, and 7.0% of breakpoints, respectively). When the breakpoints of clonal structural abnormalities were analyzed, they were shown t o cluster t o several chromosome segments, including I p I I -q2 I, 7pter, I I p 12-q 12, and 6q I 1-2 I. An analysis of the net gain or loss of specific chromosome segments was also performed, with the most consistent tendency observed being the over-representation of Iq, 6p, 7, and I I. The most frequent losses included Ip, 6q, 7, and I Iq. Genes Chrom Cancer 7:/94-203 (1993).