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Clonal B lymphocytes lack bcr rearrangement in Ph-positive chronic myelogenous leukaemia

✍ Scribed by Anna Maria Ferraris; Letizia Canepa; Cecilia Melani; Maurizio Miglino; Giorgio Broccia; Gian Franco Gaetani


Book ID
114711613
Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
359 KB
Volume
73
Category
Article
ISSN
0007-1048

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Absence of the hybrid bcr-abl mRNA in Ph
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The expression of c-abl, c-sis, c-myc and N-ras oncogenes was examined in 2 lymphoblastoid cell lines, one with Ph1 (PB-1049) and the other without Ph1 (LN-1049), both established from a patient with chronic myelogenous leukemia (CML), and in a Ph1-positive cell line (PB-1049-T) derived from a tumor