Clonal aberrations of chromosomes x, y, 7 and 10 in normal kidney tissue of patients with renal cell tumors
✍ Scribed by Angela Emanuel; Sandor Szucs; Heinz-Ulrich G. Weier; Gyula Kovacs
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 276 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1045-2257
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✦ Synopsis
By means of G-banding techniques, chromosome aberrations were studied in short-term cultures of normal renal parenchymal cells from 45 patients with renal cell carcinoma. Clonal chromosomal aberrations were detected in 29 patients; loss of the Y chromosome as well as trisorny X, 5, 7, 9, 10, 12, and 18 was found. Chromosomes 7 and 10 were involved preferentially. Results of fluorescence in sku hybridization with chromosome 7and 10-specific DNA probes on non-cultured normal kidney cells suggested that the aberrations developed in vivo. Genes Chrom Cancer 4:75-77 ( I 992).